#26 Chemical Reactions in Biology | Crash Course Biology (2024) YouTube Video Lesson

Make Chemical Reactions in Biology easier to teach with a no-prep YouTube video lesson focused on energy, ATP, chemical reactions, reactants, products, activation energy, enzymes, exergonic reactions, endergonic reactions, entropy, and coupled reactions.

Students learn how cells use energy to power chemical reactions. The video introduces ATP, reactants and products, activation energy, enzymes, exergonic and endergonic reactions, entropy, and how cells couple reactions to make life-sustaining work possible.

Use this video guide for Grades 8-12 biology, environmental science, NGSS review, science literacy, sub plans, or discussion-based classes. Use this lesson during an energy in cells lesson, enzymes introduction, ATP review, chemical reactions mini-lesson, or biology assessment review; bell-ringer extension, flipped lesson, absent-student makeup work, or review. The questions help students move beyond memorizing terms and toward explaining biology concepts with evidence, vocabulary, and concise science writing.

Crash Course Biology playlist: Teachers and students access the public video separately on YouTube. Open the Crash Course Biology playlist here.

Try it free first: Will this lesson meet your needs? Try #1 Introduction to Biology FREE and preview the format before purchasing this lesson.

Future full bundle: This lesson is part of the planned Crash Course Biology (2024) YouTube Video Lesson Bundle - All 50 Episodes.

Classroom Use at a Glance

• Best for:Grades 8-12 biology, environmental science, science literacy, NGSS review, sub plans, and guided video lessons
• Use cases:an energy in cells lesson, enzymes introduction, ATP review, chemical reactions mini-lesson, or biology assessment review; bell-ringer extension, flipped lesson, absent-student makeup work, or review
• Key themes:energy, ATP, chemical reactions, reactants, products, activation energy, enzymes, exergonic reactions, endergonic reactions, entropy, and coupled reactions
• Skills addressed:Explain how cells use energy to power chemical reactions, Use ATP, activation energy, and enzyme vocabulary in context, Compare exergonic and endergonic reactions, Connect coupled reactions to life-sustaining cellular work, Write concise explanations about energy and biological reactions
• Differentiation:students can complete the written video guide or use the 10-question multiple-choice quiz as an alternate assessment
• Time needed:video runtime plus about 20-45 minutes for discussion, written responses, and assessment
• Formats included:printable worksheet, Google Slides/PPTX, Google Forms quiz, teacher guide, answer keys, standards alignment, and Google Classroom link PDF

Guidance & Summary

• Chemical Reactions in Biology: Crash Course Biology #26 is a short educational YouTube lesson designed to help students build biology knowledge through clear explanations, examples, vocabulary, and evidence-based questions.
• Students learn how cells use energy to power chemical reactions. The video introduces ATP, reactants and products, activation energy, enzymes, exergonic and endergonic reactions, entropy, and how cells couple reactions to make life-sustaining work possible.

Differentiation Options

The teacher guide includes a written-response path and a multiple-choice quiz path.

• Use the written worksheet when students are ready to explain vocabulary, evidence, systems, cause and effect, and science concepts in more detail. Use the 10-question multiple-choice quiz when students need fewer writing demands, a faster assessment, or a more accessible review option.
• Support options include reading questions aloud, offering small-group testing, allowing extended time, previewing vocabulary, or having students explain selected answers orally.

What's Included

Student Materials

• Rigorous short-answer questions (chronological, time-stamped)
• End-of-video reflection and challenge questions
• 10-question multiple-choice quiz (Google Forms compatible)

Teacher Materials

• Teacher's guide and lesson plan
• Worksheet and MC quiz answer key
• NGSS and CCSS science literacy alignment
• Pre- and post-viewing discussion questions
• 20-minute, 30-minute, and 45-minute pacing options

Digital & Print Options

• All materials include Google Classroom and print options

Flexible Lesson Pacing

• 20-Minute Quick Clip: best for tight schedules, bell-ringers, early finisher blocks, or short sub plans
• 30-Minute Flexible Mini-Lesson: best for teachers who want the full short-answer guide while keeping the lesson compact
• 45-Minute Full Mini-Lesson: best for classes that need guided discussion, vocabulary support, and in-class writing time
• The teacher guide includes these pacing paths, plus options for written responses or the multiple-choice quiz as an alternate assessment.

Skills Addressed

• Explain how cells use energy to power chemical reactions
• Use ATP, activation energy, and enzyme vocabulary in context
• Compare exergonic and endergonic reactions
• Connect coupled reactions to life-sustaining cellular work
• Write concise explanations about energy and biological reactions
• Vocabulary in context
• Evidence-based written response
• Science literacy and academic discussion
• CCSS Anchor alignment connects vocabulary, evidence, discussion, and supported interpretation to NGSS HS-LS1-7.

Frequently Asked Questions

Can I use this as a sub plan?

Yes. The video guide includes structured questions, answer keys, flexible pacing options, and a multiple-choice quiz, so it can work as a planned science lesson or a reliable sub plan.

Does this include a digital version?

Yes. The resource includes Google Classroom-friendly materials, including digital worksheet and quiz options.

Is there an answer key?

Yes. The teacher guide includes worksheet answers and the multiple-choice quiz answer key.

How long does the resource take?

Plan for the video runtime plus about 20-45 minutes for questions, discussion, vocabulary, and written work.

How is this differentiated?

Students can complete the written-response video guide or use the 10-question multiple-choice quiz as an alternate assessment with more accessible language.

Copyright & Trademark Disclaimer: This independent, educator-created video companion is a supplemental classroom resource for discussion, comprehension, and educational analysis. It is not affiliated with, endorsed by, sponsored by, or authorized by Crash Course, Complexly, YouTube, or any related rights holders. Teachers and students access the public video separately through lawful classroom viewing methods. All trademarks and copyrights remain the property of their respective owners.